Chanca Piedra Ingredient Overview

Chanca Piedra

Ingredient-Specific Benefits

Up to 4x more potent than Rx & OTC Pain Meds

Medical Studies have shown Chanca Piedra to possess pain-relieving qualities that are several more times potent than modern pain medication- all without the harmful side effects.

Brazilian researchers have also discovered powerful, long-lasting pain-blocking activity in the roots, stems and leaves of several different species of Phyllanthus, including P.  niruri. In a book called “Cat’s Claw: Healing Vine of Peru”, Kenneth Jones, in a section of the book devoted to Chanca Piedra, states: 

“In the test system used, the extract of Phyllanthus urinaria showed about four times more potent activity than indomethacin and three times the strength of morphine against the second phase of pain which models the stage of “inflammatory” pain.  The pain model used in these tests (formalin-induced persistent pain) appears to provide a state similar to that of post-operative pain in people…the pain blockers in Phyllanthus have been identified by the Brazilians as gallic acid, ethyl ester and the steroidal compounds as beta-sitosterol and stigmasterol.” 

Calixto, et al. have pointed out that different kinds of compounds isolated from plants belonging to the genus Phyllanthus, eg., flavonoids such as quercetin and rutin, tannins, such as geraniin and furosin, benzenoids, such as ethyl gallate and methyl gallate, and the phytosterols, exhibited antinocieptive effects in mice.  With so many different pain-relieving active compounds present in these plants, the Brazilian researchers have indicated the possibility of the existence of synergistic effects between some molecules present in the extracts, and suggest future investigations of such effects.

Flavonoid Powerhouse

Chanca Piedra is an abundant source of bioactive components such as flavonoids: gallocatechin, rutin, quercetin, and kaempferol, which have well-documented anti-inflammatory and antioxidant properties.

Pump Up the Volume

Chanca Piedra is a potent natural diuretic that has demonstrated significant increases in urine volume and production in medical  research studies dating back to 1929.

The diuretic, hypotensive and hypoglycemic effects of Phyllanthus niruri were documented in a 1995 human study.  Indian researchers gave human subjects with high blood pressure Chanca Piedra leaf powder in capsules and reported a significant reduction in systolic blood pressure, a significant increase in urine volume and sodium excretion.  Chanca Piedra’s diuretic effect in humans was recorded as far back as 1929 and, in India a tablet of Chanca Piedra is sold as a diuretic there. This significant diuretic effect, and a significant reduction in systolic blood pressure in non-diabetic hypertensive individuals were attributed to a specific phytochemical in Chanca Piedra called geraniin in a 1988 study. In the above 1995 study, researchers also reported that blood sugar levels were reduced significantly in human subjects studied, with blood glucose in diabetic patients taking Chanca Piedra for 10 days.

Two other studies with rabbits and rats document the hypoglycemic effect of Chanca Piedra in diabetic animals.  In dealing with diabetic neuropathy and macular degeneration, a study documented Chanca Piedra with aldose reductase inhibition (ARI) properties.  Aldose reductases are substances that act on nerve endings exposed to high blood sugar concentration, resulting in neuropathy and macular degeneration.  Substances that inhibit these substances can prevent some of the chemical imbalances that occur and thus protect the nerve.  This ARI effect of Chanca Piedra was attributed, in part, to a plant chemical called ellagic acid.  This well-studied plant chemical has been documented with many other beneficial effects in over 300 clinical studies. It is also considered an immune system stimulator.

Destroy & Prevent Kidney Stones

Two Clinical studies conducted in 2017 (one in Brazil and the other in Romania) revealed that kidney stone count and size decreases in 67.8% of patients who consumed Chanca Piedra daily for 12 weeks.

Related Research Studies

Brazilian Journal of Urology- 2018

Chanca Piedra intake is safe and does not cause significant adverse effects on serum metabolic parameters. It increases urinary excretion of magnesium and potassium caused a significant decrease in urinary oxalate and uric acid in patients with hyperoxaluria and hyperuricosuria. The consumption of P.niruri contributed to the elimination of urinary calculi.

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Journal of Pharmacy & Pharmacology- 2017

Phyllanthus niruri is a perennial tropical shrub, which has been used for a wide range of diseases in South and south-east Asian traditional medicine, including but not limited to jaundice, diarrhea, dyspepsia, genitourinary infections and renal stones. In Brazil, where the plant is known as ‘Chanca Piedra’ or ‘stone breaker’, preparations of P. niruri are considered folk remedies for renal and vesicular calculi. Traditional medicine systems, such as Ayurvedic and Unani medicine, have utilized the leaves and fruit, to treat gallstones and jaundice. In Malay traditional medicine, P. niruri, vernacularly known as ‘dukong anak’, is used for kidney disorders and cough.

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Journal of Ethnopharmacology- Volume 205- 2017

Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus

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Journal of Ethnopharmacology- Volume 203- 2017

Recent pharmacological interventions accredited ancient antiurolithiatic claims to several plants and their formulations. The majority of antiurolithiatic plants were found to either dissolve the stones or inhibit the process of urinary stone formation. Plants such as Phyllanthus niruri L. and Elymus repens (L.) Gould, as well as herbal products including ‘Wu-Ling-San’ formula, ‘Cystone’ and ‘Herbmed’ have been proved their utility as promising antiurolithiatic medicines in the different phases of clinical trials. In addition, some of the isolated phytochemicals such as berberine, lupeol, khelin, visnagin, 7-hydroxy-2′,4′,5′-trimethoxyisoflavone and 7-hydroxy-4′-methoxyisoflavone were reported to have potent antiurolithiatic activity.

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Journal of Pharmaceutical Analysis- 2017

Phyllanthus species (Euphorbiaceae) is widely distributed through- out the tropical and subtropical countries of Africa, Asia, South America and West Indies. The plants of genus Phyllanthus such as P. emblica, P. fraternus, P. amarus and P. niruri are extensively used in Indian System of Medicine (Ayurveda and Siddha) and Traditional Chinese Medicine due to their medicinal properties for the treatment of jaundice, asthma, malaria, eczema, wart, diarrhea and headache [1–5]. The extracts of Phyllanthus species have been reported to show several biological activities such as antioxidant, hepatoprotective, hypotensive, analgesic, antihepatotoxic, antiviral, antimicrobial, anticancer, anti- amnesic, antiulcer, analgesic, antiinflammatory, antiallodynic, and anti-HIV/AIDS ones

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Journal Of Medicinal Plant Studies- 2016

Phyllanthus niruri has been used since ages by the folk because of its rich medicinal values. The broad spectrum of its medicinal use accounts for the chemical investigation of the herb. Hence, the chemical standardization of the raw material and the formulations containing Phyllanthus niruri is under vast discovery and thus more work is required to establishPhyllanthus niruri as a useful herb for treatment of various complications. Coupled with improvements in approaches for natural-product isolation, characterization and synthesis, this could be opening the door to a new era in the investigation of natural products in academia and industry.

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Brazilian Journal of Urology- 2010

The experimental studies summarized here suggest that Phyllanthus niruri might interfere with important steps of the calculi formation including crystal aggregation and internalization by the tubular cells, crystal structure and composition. These proper- ties of Phyllanthus niruri may constitute an important advantage in the prevention of lithiasis, inhibiting calculus growth and keeping the crystals dispersed in the urine, with their consequent easier elimination. Although clinical studies are less abundant, available data point to beneficial effects of Phyllanthus by in- ducing ureteral relaxation, interfering in the excretion

of promoters of urinary crystallization such as calcium or helping to clear fragments following lithotripsy. It is important to consider however, that although it is clear that Phyllanthus niruri can interfere with many steps of the stone formation, longer-term clinical stud- ies are necessary to define whether these effects can be translated into real clinical benefit to treat and/or prevent urolithiasis.

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Herbal Secrets of the Rainforest- Technical Report: Chanca Piedra- 2003

With its applications for kidney and gallstones, cellular and liver protection, hypertension and high cholesterol, cancer prevention, and its analgesic and antiviral effects, it is gaining in popularity on many continents as an herbal remedy. It's also important to note than in all the research published over the last 20 years, no signs of toxicity or side effects have been reported in any of the human or animal studies, even in acute or chronic use. Animal studies report no genotoxic, mutagenic or carcinogenic effects.

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Brazilian Journal of Urology- 2002

These results show that Pn has an inhibitory effect on crystal growth, which is independent of changes in the urinary excretion of citrate and Mg, but might be related to the higher incorporation of GAGs into the calculi.

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Beijing University of Chinese Medicine- 2016

The plants of the genus Phyllanthus (Euphorbiaceae) have been used as traditional medicinal materials for a long time in China, India, Brazil, and the Southeast Asian countries. They can be used for the treatment of digestive disease, jaundice, and renal calculus. This review discusses the ethnopharmacological, phytochemical, and pharmacological studies of Phyllanthus over the past few decades.

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Journal of Ethnobiology and Ethnomedicine 2006

This paper examines the traditional use of medicinal plants in Northern Peru, with special focus on the Departments of Piura, Lambayeque, La Libertad, Cajamarca, and San Martin. 510 plant species used for medicinal purposes were collected, identified and their vernacular names, traditional uses and applications recorded. The families best represented were Asteraceae with 69 species, Fabaceae (35), Lamiaceae (25), and Solanaceae (21). Euphorbiaceae had twelve species, and Apiaceae and Poaceae 11 species.

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Asian Pacific Journal of Tropical Medicine- 2014

Five non-smoking, male healthy volunteers, 20 to 31 years old, were enrolled. Each subject was treated twice, following a randomized crossover fashion regarding the ingestion of P. niruri infusion (5 g/750 mL) (tea group) or 750 mL of water (control group). Fasting venous blood samples were collected prior to and at 1, 2 and 4 h after infusion drinking. Samples were tested for plasmatic gallic acid and ascorbic acid levels, erythrocytic catalase and superoxide dismutase activities, and intracellular DCFH fluorescence in granulocytes, monocytes and lymphocytes.

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Future Studies

Researchers have suggested that another promising area for future study would be the use of Chanca Piedra in treatment of Lyme Disease.  Since syphilis is caused by a spirochete and Chanca Piedra has traditionally been used for this illness, it would be a good study for the epidemic of Lyme Disease, which we are experiencing the northeastern United States, since Lyme is also caused by a spirochete.  Some herbalists have used Chanca Piedra traditionally for gonorrhea and syphilis.

Chanca Piedra is a perfect example of a highly beneficial medicinal plant, which is deserving of much more research.  Unfortunately, because of its complicated myriad of chemical constituents, there isn’t enough grant monies available.  Major funding would have to be had for a pharmaceutical or research company to isolate a single, patentable chemical to justify the high cost of research. 

CONTRAINDICATIONS

There has been no toxicity reported in any of the clinical studies, nor have there been any side effects reported, except for an occasional case of cramps during the expulsion of stones from the use of the whole plant either as a tea or in “crude” (whole plant) extracts in capsules.  If cramping occurs, dosage can be cut in half. 

Although scientific studies have indicated Chanca Piedra is safe for pregnant women to take, documented ethnic uses in Brazil indicate its use as an abortive by rural populace (effect seen at higher doses), presumably due to the smooth muscle relaxant properties.  Therefore, if taken during pregnancy, it is recommended that doses of Chanca Piedra be kept low, especially during the first trimester.  As with any supplements used while pregnant or nursing, consult your health care practitioner.

Chanca Piedra has been documented in human and animal studies with diuretic effects.  Chronic and acute use of this plant may be contraindicated in various other medical conditions where diuretics are not advised.  Chronic long-term use of any diuretic can cause electrolyte and mineral imbalances; however, human studies with Chanca Piedra (for up to three months of chronic use) have not reported any side effects.  Consult your doctor if you choose to use this plant chronically for longer than three months concerning possible side effects of long-term diuretic use.

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